CPFA : Coupled Plasma Filtration Adsorption
CPFA is designed to remove some specific large substances by plasmaperfusion in-line with CVVH which replaces the kidney failure. CPFA is performed according to the clinical situation, from 1 to 5 daily sessions.
Examples of application
- Severe sepsis
- Septic shock
- Acute liver failure
- ABO incompatible renal transplant
CPFA, is a 3 steps technic where first blood is passed through a plasmafilter, the obtained plasma being sent to a sorbent which retains some specific substances, such as cytokines or bilirubin, before returning the plasma to the blood. A hemofilter placed on the blood flow then allows to perform a hemofiltration which compensates for the kidney failure often associated to the main disease.