Plasma Therapies History

Heden is historically the father of the plasma therapies as he was the first to re-transfuse erythrocytes (Red Blood Cell’s) in dogs and Rabbit in 1902.

The first human application was done by Dr Fleig who treated a patient with uraemia (low level of blood cells) in 1909.  However the term Plasmapheresis was defined by Pr Abel in USA in 1914, combining two concepts : 

Thus, plasmapheresis was totally defined as a method of selective removal of plasma from an organism.

Unfortunately the First World War began which stopped the experiments and this technical approach was forgotten for a few decades.

In 1944, Swedish physician Jan G. Waldenström described a case of Macroglobulinemia with symptoms of increased blood viscosity. In 1955, Jan G. Walderstrom performed effective plasmapheresis procedure on a patient with macroglobulinemia and noted a effective reduction of macroglobulin in the blood.

In 1963, several procedures were successfully performed on patients with Waldemström illness (Macroglobulinemia with blood viscosity)

Plasmapheresis application is really activ in many countries since the 70’s with approximately 1000 procedures in England, 6200 in France and later in the 80’s with 50 000 procedures in USA.

Today the term plasmapheresis includes different techniques (filtration or adsorption on plasma), which remove not all but only specific elements contained in the plasma, and altogether allow to treat a large number of diseases.

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